Found 12 matching trials
FUS Etoposide for DMG PHASE1 The blood brain barrier (BBB) prevents some drugs from successfully reachin...
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Columbia University Irving Medical Center
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Intravenous Immunoglobulin (IVIG) and Blood-Brain Barrier Disruption in Amyotrophic Lateral Sclerosis (ALS) PHASE1 The goal of this study is to evaluate the safety and feasibility of IVIg ad...
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Active Not Recruiting
Location
Sunnybrook Health Sciences Centre
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Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy EARLY_PHASE1 The purpose of this study is to assess the safety and feasibility of admini...
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Active Not Recruiting
Location
West Virginia University Rockefeller Neuroscience Institute
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Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM) PHASE1 This will be a prospective, open-label, single-arm pilot study to investiga...
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University of Virginia
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Efficacy and Safety of NaviFUS System add-on Bevacizumab (BEV) in Recurrent GBM Patients NA This is a prospective, single-arm, two stages, open-label, pilot study to i...
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Linkou Chang Gung Memorial Hospital
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Focused Ultrasound Blood-Brain Barrier Disruption for the Treatment of High-Grade Glioma in Patients Undergoing Standard Chemotherapy PHASE1 The goal of this clinical trial is to evaluate the safety and feasibility o...
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Sunnybrook Health Sciences Centre
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Non-Invasive Focused Ultrasound (FUS) With Oral Panobinostat in Children With Progressive Diffuse Midline Glioma (DMG) PHASE1 The blood brain barrier (BBB) prevents some drugs from successfully reachin...
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Columbia University Irving Medical Center / NewYork-Presbyterian Hospital
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Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau PHASE1 The primary purpose of this phase 1b study is to further assess the safety ...
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Columbia University Irving Medical Center
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ExAblate Blood-Brain Barrier Opening for Treatment of Alzheimer's Disease NA The purpose of this study is to evaluate the safety and efficacy of the ExA...
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Division of Neurosurgery, Sunnybrook Health Sciences Centre
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Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES) PHASE1 This study is for people (children and adults) with a rare and aggressive b...
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Princess Maxima Center for pediatric oncology
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